WP5: Biomagnetic control of stem cell differentiation

Magnetic particles have been employed to study the way mechanical forces effect neuronal cells as they allow the application of defined levels of force, locating the particles to specific regions of the cell membrane using particle coatings. Using these techniques, it is possible to apply forces of physiological stresses without either detachment of the particles or cell membrane damage. We have screened mechanoreceptors and demonstrated activation of receptors which control stem cells to form mature neuronal tissues.  These strategies for combining magnetic fields and nanoparticles can be used for stimulating the differentiation of neurons and promoting neuronal fibre outgrowth to different regions in the brain.

Our aims within WP5 are to use novel cross-disciplinary methods by which specific mechano-receptors in the cell membrane can be tagged with magnetic particles for the purpose of controlling neuronal cell differentiation. Development of these strategies are very challenging but if successful will ultimately allow us to direct cell differentiation and proliferation using tissue engineering approaches and cell therapy treatments for Parkinson’s disease

WP5: Biomagnetic control of stem cell differentiation:

 

Magnetic particles have been employed to study the way mechanical forces effect neuronal cells as they allow the application of defined levels of force, locating the particles to specific regions of the cell membrane using particle coatings. Using these techniques, it is possible to apply forces of physiological stresses without either detachment of the particles or cell membrane damage. We have screened mechanoreceptors and demonstrated activation of receptors which control stem cells to form mature neuronal tissues.  These strategies for combining magnetic fields and nanoparticles can be used for stimulating the differentiation of neurons and promoting neuronal fibre outgrowth to different regions in the brain.

 

Our aims within WP5 are to use novel cross-disciplinary methods by which specific mechano-receptors in the cell membrane can be tagged with magnetic particles for the purpose of controlling neuronal cell differentiation. Development of these strategies are very challenging but if successful will ultimately allow us to direct cell differentiation and proliferation using tissue engineering approaches and cell therapy treatments for Parkinson’s disease