Press

Scientific Publications

The results of the Magneuron project made possible to publish the following articles :

This articles are free to access, just click on the title of the publication


 

 

- Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons

Schöneborn H, Raudzus F, Coppey M, Neumann S, Heumann R. (to appear in Int J Mol Sci)

Magnetic Control of Cellular Processes using Biofunctional Nanoparticles   

C. Monzel, C. Vicario, J. Piehler, M. Coppey, M. Dahan, (to appear in Chemical Science).

Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells

D. Lisse, C. Monzel, C. Vicario, I. Maurin, J. Manzi, M. Coppey, J. Piehler, and M. Dahan, (to appear in Advanced Materials).

Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain InjuryProtection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury

Serdar M, Herz J, Kempe K, Winterhager E, Jastrow H, Heumann R, Felderhoff-Müser U, Bendix I, (to appear in Frontiers in Neurology)

Rheb in neuronal degeneration, regeneration, and connectivity

Potheraveedu VN, Schöpel M, Stoll R, Heumann R, (to appear in Biological Chemistry)

Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells

Etoc F, Balloul E, Vicario C, Normanno D, Liße D, Sittner A, Piehler J, Dahan M, Coppey M, (to appear in Nature Materials)

- Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells

Drees C, Naduviledathu Raj A, Kurre R, Busch K, Haase M, Piehler J (to appear in Gesellschaft Deutscher Chemiker)

Lethal factor domain-mediated delivery of Nurr1 Transcription Factor enhances Tyrosine Hydroxylase activity and protects from neurotoxin-induced degeneration of dopaminergic cell

Dennis Paliga, Fabian Raudzus, Stephen H. Leppla, Rolf Heumann, Sebastian Neumann, ( to appear in Molecular Neurobiology)

 

 

Do you want to learn more ?

Look at our subjets related publications from our project partners:

-    Heumann R, Kortholt A, «  The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2 » (to appear in Biological Chemistry)

-    Serchov T, Heumann R, « Ras Activity Tunes the Period and Modulates the Entrainment of the Suprachiasmatic Clock » (to appear in Frontiers in Neurology)

-    Schöpel M, Potheraveedu VN, Al-Harthy T, Abdel-Jalil R, Heumann R, Stoll R, « The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function » (to appear in Biological Chemistry)

-    Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M,  « Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease » (to appear in Human Molecular Genetics)

-    Athanasopoulos PS, Jacob W, Neumann S, Kutsch M, Wolters D, Tan EK, Bichler Z, Herrmann C, Heumann R, « Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2 » (to appear in Biological Chemistry)

Project Deliverables

Dissemination deliverables
Brochure pdf-bouton Download
Dissemination plan pdf-bouton Download
Dissemination Strategy Report pdf-bouton Download
Second Dissemination Strategy Report pdf-bouton Download
Data Management Plan pdf-bouton Download
Intermediate workshop pdf-bouton Download
Technical deliverables
Dispersions of stabilized MNPs pdf-bouton Download
Dispersion of silica core-shell MNPs pdf-bouton Download
Recombinant ferritin-based MNPs pdf-bouton Download
Activitation of intracellular membrane-anchored small G-proteins by cytosolic MNPs pdf-bouton Download
Characterization of magnetic manipulation in cells pdf-bouton Download
Magnetic array for the manipulation of magnetic nanoparticles inside living cells pdf-bouton Download
Protocols for activation of neuronal differentiation through key receptor tags pdf-bouton Download

 

 

MAGNEURON consortium

To achieve our ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edge know-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronal cell differentiation, stem cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise, a novel, versatile technology for magnetic control of intracellular signaling is envisaged, which will be a breakthrough for remote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injuries within the following decade.

The consortium is made of six partners (with highly complementary expertise in Physical-Chemistry, Bio-chemistry, Biophysics, Nanosciences, Neurosciences, Regenerative medicine, and Project management) from three different countries (France, Germany, UK).


 

Institut Curie

Institut Curie is a French non-profit organization and foundation of public interest created in 1921, which combines one of the largest European oncology research center and two state-of-the-art hospitals, with 3,000 researchers, physicians, clinicians, technicians and administrative staff. The Research Centre (27000 square meters) gathers about 850 staff scientists, including 200 graduate students and visitors, 200 postdoctoral fellows (from 45 nationalities) and 100 medical students. It consists of 14 departments or units, composed of physicists, chemists, biologists and clinicians, investigating fundamental and applied biomedical questions.

Department of Physical Chemistry includes 12 teams, composed of physicists, biologists and chemists. Its research activity aims to elucidate the role of physical and chemical processes in the architecture and functional dynamics of living matter. The department leader is Dr. Mathieu Coppey.

Photo Mathieu Coppey

  Dr. Mathieu Coppey

  MAGNEURON project manager

  Phone: +33 (0)1 56 24 67 81

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


 

Phenix laboratory

Phenix laboratory is a joint research unit which belongs to Centre National de la Recherche Scientifique (CNRS), a government-funded research organization under the administrative authority of French Ministry in charge of research, and University Pierre et Marie Curie (UPMC), the leading French scientific and medical university, with its 120 research laboratories and its 3500 doctoral students. The research activity of Phenix laboratory, which includes 3 teams, deals with the study of physico-chemical properties of electrolytes, nanomaterials and interfaces.

The Inorganic Colloids team (1 technician, 1 engineer, 10 researchers, 5 PhD students, 2 post-doc) is working since more than 30 years in the field of inorganic colloids. Chemists and physicians from this team are specialized in the synthesis and characterization of nanoparticles, especially magnetic ones. An important expertise has been accumulated over the years dealing with the synthesis of very high concentrated stable dispersions of those magnetic nanoparticles in aqueous or organic media (ferrofluid). Hybrid systems like magnetic liposomes, polymersomes or core shell nanoparticles have been also designed for biomedical applications. The Inorganic Colloids team is led by Dr. Christine Ménager.

 

  Dr. Christine Ménager

  Phone: + 33 1 44 27 30 47

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


 

Keele University

The Institute for Science and Technology in Medicine (ISTM) is a flagship research institute for the university comprising a multi-disciplinary partnership between Keele University and four hospital sites, including the University Hospital of North Staffordshire. The institute has an international reputation for bio-engineering with a major focus on developing technologies for regenerative medicine and advanced therapeutics. ISTM comprises over eighty academic and clinical members with 90% of staff rated of international quality in the most recent (2008) UK Research Assess-ment Exercise. The institute has strong links with industry including founding the spin-out companies Nanotherics, MICA Biosystems and Nuovoprobe. 

Neil

  Dr. Neil Telling

  Phone: +44 (0)1782 674968

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


 

Birmingham University

The University of Birmingham (UoB) has recently invested £3.5 million in building a new Healthcare Technologies Institute (HTI), which is part of a major initiative to accelerate medical device innovation in answer to the government’s industrial strategy. The HTI brings together engineers and scientists with clinicians in 1200m2 of new laboratory space, including cell biology, imaging and wet chemistry facilities that shall be accessed by this partnership. This facility will run within ISO standards and GMP manufacture with support in trial design, entrepreneurship and regulation provided by a central team within the Institute of Translation Medicine (ITM) driving new concepts to clinic.

Alicia El Haj photo 2019

  Dr. Alicia El Haj

  Phone: + 44 (0) 121 371 7698

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


The University of Osnabruck

The University of Osnabrück was founded in the early 1970s and currently has more than 12,000 students studying in 10 faculties supported by approximately 1,600 staff members. The university supports 90 partnership agreements with universities worldwide, and 140 LLP agreements with partner universities in the European Union.

The Biophysics Division at the Department of Biology of the University of Osnabrück promotes research and teaching in molecular and cellular biophysics. Our mission is to bridge the gap between the biological and the physicochemical perspective on cellular processes. To this end we have developed a broad spectrum of biophysical tools for quantifying molecular functions in complex environment, often in the context of lipid membranes. We apply these tools for unraveling the mechanistic determinants of signal transduction across the plasma membrane and we share them in numerous collaborations at the Department of Biology and beyond. Within several Bachelor and Master Courses, we introduce the inherently interdisciplinary concepts of biophysics, which we believe are pivotal for fundamental progress in the understanding of life. The Head of the Biophysics Division is Prof. Dr. Jacob Piehler.

Afficher l'image d'origine

  Dr. Jacob Piehler

  Phone: +49 (0)541 969-2800

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


 

The Ruhr-University Bochum

The Ruhr-University is ranking within the top 10 largest universities in Germany. 6 Research Departments focus on different research priorities, one of it is neuroscience. Within the framework of the German Excellence Initiative, the Deutsche Forschungsgemeinschaft (DFG) funds The Cluster of Excellence RESOLV (Ruhr Explores Solvation: EXC 1069).

The main research focus of The Heumann laboratory lies on the investigation of the signalling small GTPase Ras in a neuronal context serving as an “intracellular neurotrophin”. A transgenic mouse model was generated in which permanent activated H-Ras is expressed specifically in neurons showing protection against lesion-induced degenera-tion in the brain. More recently, the generation of dopaminergic neurons derived from neurospheres containing stem cells has been achieved. Furthermore, there is expertise in applying (calcium phosphate) nanoparticles in cellular systems. The research group comprises 2 technicians, 5 PhD students, 1 post-doc, 1 principal investigator.

Afficher l'image d'origine

  Dr. Rolf Heumann

  Phone: +49(0)234-32-24230

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


 

Efficient Innovation

Created in 1997, Efficient Innovation is a French consulting company specialized in the field of innovation management with a vision of the whole innovation value chain, from opportunities generation with strategic creativity, to concept transformation into innovation projects, market studies and opportunities building, funding of the innovation projects through direct and indirect funds for companies. Efficient Innovation is specialist in European framework programmes since FP5, FP6, FP7 and has built up many European projects. Efficient Innovation offers services of European project management to its customers with is know-how and knowledge of FP European mechanisms, consortium agreement management, grant agreement management, dissemination activities. Efficient is also a specialist in industrial product design-to-cost, design-to-weight and life cycle analysis. With a team of more than 50 consultants, EFFICIENT covers the full innovation management process. 

P14102513

  Pierre Joly

  Project Office

  Phone: +33 (0)6 10 61 06 81

  E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Recent News

Magneuron will host its second workshop as satellite meeting of the GBM/DGZ Fall conference on 23-24 September

To register please file the form on the

Sixth meeting of Magneuron project

On the 16th and the 17th May 2019, the sixth meting of the project was held in Keele University (United Kingdom). For the first time external spakers were in

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 686841.

About MAGNEURON

To achieve our ambitious goal, we have gathered an interdisciplinary consortium interfacing scientists having cutting-edge know-how in bMNP engineering, surface functionalization and cellular nanobiophysics with renowned experts in neuronal cell differentiation, stem cell reprogramming and regenerative (nano-)medicine. By exploiting this complementary expertise, a novel, versatile technology for magnetic control of intracellular signaling is envisaged, which will be a breakthrough for remote actuation of cellular functions and its successful implementation in CTs for neurodegenerative diseases and injuries within the following decade.

The consortium is made of six partners (with highly complementary expertise in Physical-Chemistry, Bio-chemistry, Biophysics, Nanosciences, Neurosciences, Regenerative medicine, and Project management) from three different countries (France, Germany, UK).


Institute Curie

Institut Curie is a French non-profit organization and foundation of public interest created in 1921, which combines one of the largest European oncology research center and two state-of-the-art hospitals, with 3,000 researchers, physicians, clinicians, technicians and administrative staff. The Research Centre (27000 square meters) gathers about 850 staff scientists, including 200 graduate students and visitors, 200 postdoctoral fellows (from 45 nationalities) and 100 medical students. It consists of 14 departments or units, composed of physicists, chemists, biologists and clinicians, investigating fundamental and applied biomedical questions. Under FP7, the institute has hosted 24 ERC grants, 21 Marie-Curie grants and 20 European cooperation projects.

Department of Physical Chemistry. The department includes 12 teams, composed of physicists, biologists and chemists. Its research activity aims to elucidate the role of physical and chemical processes in the architecture and functional dynamics of living matter.

CRNS & UPMC

Phenix laboratory is a joint research unit which belongs to Centre National de la Recherche Scientifique (CNRS), a government-funded research organization under the administrative authority of French Ministry in charge of research, and University Pierre et Marie Curie (UPMC), the leading French scientific and medical university, with its 120 research laboratories and its 3500 doctoral students.

The research activity of Phenix laboratory, which includes 3 teams, deals with the study of physico-chemical properties of electrolytes, nanomaterials and interfaces. The Inorganic Colloids team (1 technician, 1 engineer, 10 researchers, 5 PhD students, 2 post-doc) is working since more than 30 years in the field of inorganic colloids. Chemists and physicians from this team are specialized in the synthesis and characterization of nanoparticles, especially magnetic ones. An important expertise has been accumulated over the years dealing with the synthesis of very high concentrated stable dispersions of those magnetic nanoparticles in aqueous or organic media (ferrofluid). Hybrid systems like magnetic liposomes, polymersomes or core shell nanoparticles have been also designed for biomedical applications.

Keele University

The Institute for Science and Technology in Medicine (ISTM) is a flagship research institute for the university comprising a multi-disciplinary partnership between Keele University and four hospital sites, including the University Hospital of North Staffordshire. The institute has an international reputation for bio-engineering with a major focus on developing technologies for regenerative medicine and advanced therapeutics. ISTM comprises over eighty academic and clinical members with 90% of staff rated of international quality in the most recent (2008) UK Research Assess-ment Exercise. The institute has strong links with industry including founding the spin-out companies Nanotherics, MICA Biosystems and Nuovoprobe. The institute provides a dynamic training environment for early-career researchers and participates in international programmes such as FP7 China-Europe exchange programme (http://www.keele.ac.uk/hyanjiscaffold/), and the Marie Curie Initial Training ITN MagneticFUN’ (http://www.magneticfun.eu).

Universität Osnabrück

The University of Osnabrück was founded in the early 1970s and currently has more than 12,000 students studying in 10 faculties supported by approximately 1,600 staff members. The university supports 90 partner-ship agreements with universities worldwide, and 140 LLP agreements with partner universities in the European Union.

Department of Biology. The department includes 14 divisions covering the entire spectrum of biology, comprising biologists, biochemists and chemists. One major research focus is the physiology and dynamics of cellular microcom-partments, which is funded by the German Science Foundation since 2011. Within the research center “Cellular Nanoanalytics”, a dedicated interdisciplinary institute for development of advanced light and electron microscopy is currently being established together with Physics, Chemistry and Mathematics.

Ruhr-Universität Bochum

The Ruhr-University is ranking within the top 10 largest universities in Germany. 6 Research Departments focus on different research priorities, one of it is neuroscience. Within the framework of the German Excellence Initiative, the Deutsche Forschungsgemeinschaft (DFG) funds The Cluster of Excellence RESOLV (Ruhr Explores Solvation: EXC 1069).

The main research focus of the Heumann Laboratory lies on the investigation of the signalling small GTPase Ras in a neuronal context serving as an “intracellular neurotrophin”. A transgenic mouse model was generated in which permanent activated H-Ras is expressed specifically in neurons showing protection against lesion-induced degenera-tion in the brain. More recently, the generation of dopaminergic neurons derived from neurospheres containing stem cells has been achieved. Furthermore, there is expertise in applying (calcium phosphate) nanoparticles in cellular systems. The research group comprises 2 technicians, 5 PhD students, 1 post-doc, 1 principal investigator.

Efficient Innovation

Created in 1997, Efficient Innovation is a French consulting company specialized in the field of innovation management with a vision of the whole innovation value chain, from opportunities generation with strategic creativity, to concept transformation into innovation projects, market studies and opportunities building, funding of the innovation projects through direct and indirect funds for companies. Efficient Innovation is specialist in European framework programmes since FP5, FP6, FP7 and has built up many European projects. Efficient Innovation offers services of European project management to its customers with is know-how and knowledge of FP European mechanisms, consortium agreement management, grant agreement management, dissemination activities. Efficient is also a specialist in industrial product design-to-cost, design-to-weight and life cycle analysis. With a team of more than 50 consultants, EFFICIENT covers the full innovation management process.

Recent News

Magneuron will host its second workshop as satellite meeting of the GBM/DGZ Fall conference on 23-24 September

To register please file the form on the

Sixth meeting of Magneuron project

On the 16th and the 17th May 2019, the sixth meting of the project was held in Keele University (United Kingdom). For the first time external spakers were in

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 686841.

The Project

The aim of this project is to introduce a fundamentally new concept for remote control of cellular functions by means of magnetic manipulation. The technology is based on magnetic nanoparticles functionalized with proteins involved in cellular signalling cascades. These bio-functionalized MNPs (bMNPs) will be delivered into target cells, where they act as intracellular signalling platforms activatable in a spatially and temporally controlled manner by external magnetic fields.

The key objectives of our proposal are:

  • the development of the chemical, biochemical and physical tools for the magnetic control of signalling in stem cells and neuronal cells,
  • the demonstration of magnetic actuation of differentiation and oriented growth of DA precursor neurons in single-cell in vitro assays
  • the application of the technology with cells transplanted into organotypic brain slices and rodents.

By the end of the project, we will have reached a conceptual and practical expertise for the magnetic control of signalling activity in cells, with a demonstrated proof-of-concept for the differentiation and growth of stem cell derived neuronal cells in cultures, tissues and animals. This unique expertise will serve as foundation for subsequent applications of our technology in animal models and patients.

Recent News

Magneuron will host its second workshop as satellite meeting of the GBM/DGZ Fall conference on 23-24 September

To register please file the form on the

Sixth meeting of Magneuron project

On the 16th and the 17th May 2019, the sixth meting of the project was held in Keele University (United Kingdom). For the first time external spakers were in

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 686841.